Differential Diagnosis in Adults with Low ALP
Availability
Registration Required
Expires on May 07, 2026
Online Meeting
Apr 09, 2026 4:00 PM - 5:00 PM ET
Cost
$0.00
Credit Offered
No Credit Offered
  • Description
  • Target Audience
  • Learning Objectives
  • Faculty and Disclosures

Low serum alkaline phosphatase (ALP) in adults is associated with a range of conditions, from acquired disorders such as malnutrition and hypothyroidism to rare genetic diseases like hypophosphatasia (HPP). However, limited awareness and unclear diagnostic pathways often lead to delayed diagnosis and inappropriate management.

This non-accredited webinar will help healthcare professionals recognize the clinical significance of low ALP, navigate key challenges in differential diagnosis, and apply current diagnostic tools to improve timely and accurate identification of underlying conditions.

This program is intended for endocrinologists, primary care providers, physician associates (PAs), nurse practitioners (NPs), and nurses involved in the evaluation and management of adult patients with low alkaline phosphatase (ALP) and related metabolic bone disorders.

  1. Recognize the physiological signs of low ALP and distinguish between potential causes of low ALP levels.
  2. Assess when to test for low ALP levels and summarize the diagnostic workflow for low ALP.
  3. Interpret ALP testing results and determine whether further testing is necessary for diagnosis.
  4. Develop multidisciplinary care coordination strategies to streamline the diagnostic pathway for HPP.

Aliya Khan, MD, FRCPC, FACP, FACE, FASBMR 
Clinical Professor, Medicine, Division of Endocrinology and Geriatrics, Director of the Calcium Disorder Clinic, Director of the Fellowship in Metabolic Bone Disease, McMaster University.

STATEMENT OF INDEPENDENCE
As a provider of CME accredited by the Accreditation Council for Continuing Medical Education, the Endocrine Society has a policy of ensuring that the content and quality of this educational activity are balanced, independent, objective, and scientifically rigorous. The scientific content of this activity was developed under the supervision of the Endocrine Society’s peer reviewers.

DISCLOSURE POLICY
The faculty, committee members, and staff who are in position to control the content of this activity are required to disclose to the Endocrine Society and to learners any relevant financial relationship(s) of the individual that have occurred within the last 12 months with any commercial interest(s) whose products or services are related to the content. Financial relationships are defined by remuneration in any amount from the commercial interest(s) in the form of grants; research support; consulting fees; salary; ownership interest (e.g., stocks, stock options, or ownership interest excluding diversified mutual funds); honoraria or other payments for participation in speakers' bureaus, advisory boards, or boards of directors; or other financial benefits. The intent of this disclosure is not to prevent planners with relevant financial relationships from planning or delivery of content, but rather to provide learners with information that allows them to make their own judgments of whether these financial relationships may have influenced the educational activity with regard to exposition or conclusion.

The Endocrine Society has reviewed all disclosures and resolved or managed all identified conflicts of interest, as applicable.

The faculty reported the following relevant financial relationship(s) during the content development process for this activity: 

Aliya Khan, MD, FRCPC, FACP, FACE, FASBMR:
Speaker, Alexion, Amgen, Shire/Takeda, Ultragenyx, Chugai; Reasearch Grants, Alexion, Amgen, Takeda, Ultragenyx, Chugai, Radius, Ascendis, Amolyt; Consultant, Alexion, Amgen, Takeda, Ultragenyx, Chugai, Radius, Ascendis, Amolyt

The following member who reviewed content for this activity reported no relevant financial relationships:

Dr. DALAL S A H M ALI, MD, MSc, FRCPI

The Endocrine Society staff involved in the development of this CME activity reported no relevant financial relationships.

The Endocrine Society staff have reviewed all disclosures and resolved or managed all relevant identified conflicts of interest, as applicable.

Acknowledgement of Commercial Support: 
This educational activity is supported by a sponsorship from Alexion. 

   
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