Turner syndrome is one of the most common chromosomal anomalies in females, caused by loss of part of X chromosome or all of it. Its incidence varies from 1 in 2000 to 1 in 2500 live female births. It is an important cause of short stature and primary and or premature ovarian insufficiency in females. It also affects other organ systems and females with this condition are at high risk of developing various multisystem manifestations including hypertension, aortic root dilatation and dissection, renal anomalies, osteoporosis, fatty liver, high risk of malignancies, metabolic syndrome, type 2 diabetes, and hearing abnormalities. In most of the females, short stature, abnormalities of menstruation, and puberty are the presenting symptoms. Endocrinologists are usually involved in the care of these patient early on. However, in view of multisystem involvement, a coordinated holistic approach is required for the better outcomes in these patients. Endocrinologists are well placed to take the lead in holistic care of these patients and coordinate multidisciplinary care.At The Christie Hospital, Manchester, we hold a dedicated Turner syndrome service. Holistic approach in long-term management of these patients will be discussed.
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