This is a recording of the live webinar presentation on March 28, 2023.
Checkpoint inhibitors are immunomodulatory antibodies used to enhance immune system and have substantially improved outcomes in various malignancies at advanced stages. Programmed cell death receptor 1 (PD-1), programmed cell death ligand 1 (PD-L1) and Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) are the primary targets for checkpoint inhibition. These drugs have a unique spectrum of side effects, termed as irAEs(immune related adverse events).Overall incidence of clinically significant endocrinopathies is approximately 10 percent of patients treated with checkpoint inhibitors; thyroid, pituitary and adrenal glands are most commonly affected. Acute onset type 1 diabetes like presentation is also described as a rare side effect.
Endocrinology input is often necessary in the holistic management of these patients and awareness among the endocrine community is important. This webinar will review the diagnosis and management of these conditions from endocrine point of view.
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The faculty reported no relevant financial relationships.The Endocrine Society staff report no relevant financial relationships.