When the Immune System Gets It Wrong!-When the Immune System Gets It Wrong!

Video Transcription

Video Summary

Summary:<br /><br />The first video focuses on immune-related adverse effects of immune checkpoint inhibitors, specifically immune checkpoint inhibitor thyroiditis. Dr. Melissa Lek discusses how immune tolerance becomes dysregulated in the thyroid and highlights the role of IL-17 in checkpoint inhibitor thyroiditis. She presents evidence from a mouse model suggesting that blocking IL-17 can reduce thyroid autoimmunity without impairing antitumor responses. Other immune modulating therapies used in inflammatory bowel disease and psoriasis are also mentioned as potential treatments for autoimmune thyroid disease. The video concludes with a Q&A session.<br /><br />In the second video, the speaker explores the impact of hormones on the immune system and their association with T-cell and B-cell populations. They identify genetic variants involved in immune functions and emphasize the bidirectional interaction between thyroid hormones and the immune system. The speaker emphasizes the need for further studies to understand the clinical implications and improve therapeutic approaches.<br /><br />In the third video, the speaker discusses the role of thyroid hormones in cancer pathology. They find that thyroid hormones directly impact immune cells and can regulate immune function. They also observe that thyroid hormones can directly affect tumor growth and angiogenesis. In animal models, hyperthyroidism leads to larger tumors with increased metastatic spreading, while hypothyroidism results in smaller tumors with decreased metastatic spreading. The speaker suggests that monitoring the thyroid axis and restoring euthyroidism in immunocompromised patients may be crucial in cancer treatment.<br /><br />No specific credits are mentioned in the video summaries.

Keywords

immune checkpoint inhibitors

immune checkpoint inhibitor thyroiditis

IL-17

mouse model

thyroid autoimmunity

immune modulating therapies

autoimmune thyroid disease

hormones

T-cell populations

thyroid hormones

cancer pathology

tumor growth

euthyroidism


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