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Updates in Hypothyroidism Treatment – New Evidence ...
Hypothyroidism T3 Recording
Hypothyroidism T3 Recording
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Video Transcription
Video Summary
Dr. Thanh Hoang, an endocrinology expert, provided a comprehensive overview of hypothyroidism, focusing on diagnosis, treatment, and new evidence regarding T3 combination therapy. Primary hypothyroidism, mostly due to autoimmune Hashimoto's thyroiditis, is common, and levothyroxine (T4) remains the standard treatment. Challenges include under- or over-replacement and persistent symptoms despite normal TSH levels. Diagnosis relies on biochemical tests with TSH and free T4 measurements. Historical treatments evolved from desiccated thyroid extract (DTE) to synthetic hormones. DTE contains T3 and T4 in a fixed ratio, offering some patients symptom relief compared to T4 alone.<br /><br />Dr. Hoang reviewed clinical trials showing about one-third of patients with ongoing symptoms on levothyroxine prefer combination therapies (DTE or synthetic T3/T4), reporting better quality of life and cognitive function without adverse effects. Timing and dosing of levothyroxine are critical for effectiveness, with recommendations for monitoring TSH every 6-8 weeks initially. Drug interactions and patient compliance affect therapy outcomes.<br /><br />Recent guidelines allow combination therapy trials for patients with persistent symptoms. Dr. Hoang emphasized using the thyroid symptom questionnaire to identify patients who might benefit from combination therapy. Future research aims for personalized treatment, ideal T3/T4 ratios, and new drug formulations. Overall, combination therapies are safe and effective alternatives for selected hypothyroid patients not fully satisfied with levothyroxine monotherapy.
Keywords
hypothyroidism
levothyroxine
T3 combination therapy
Hashimoto's thyroiditis
desiccated thyroid extract
thyroid function tests
thyroid symptom questionnaire
combination therapy guidelines
patient compliance
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