The Many Faces and Phases of Co-Regulators-The Many Faces and Phases of Co-Regulators

Video Transcription

Video Summary

The first video features Dr. Daniel Joelle and Dr. Denise Okafor introducing a session on co-regulators. The session includes four presentations discussing the roles and interactions of co-regulators with nuclear receptors, transcription factors, and modifying enzymes. The topics include the composition of transcriptional complexes, the regulatory roles of co-regulators in metabolism and inflammation, and their involvement in prostate cancer cell proliferation. The session is a hybrid format with both in-person and online participation. The first speaker, Dr. Murray Campbell, discusses the role of NCoR2 in prostate cancer progression, highlighting its interaction with transcription factors and its impact on gene expression. The second speaker, Dr. Jennifer Estal, focuses on the molecular changes involving diabetes and metabolic illnesses, specifically discussing PGC-1 alpha and its role in regulating various processes. Both presentations emphasize the importance and complexity of co-regulators in biological processes.<br /><br />In the second video, Professor Henriette Uhlenholt discusses the complexity of glucocorticoid receptor (GR) regulation of transcription in primary mouse macrophages. The study investigates the co-regulator complexes involved in GR action, with chromatin remodelers and histone methyl transferases being identified as the main complexes. The SETD1A complex of H3K4 methyl transferases and the MLL-BRG1-Switch-SNF complex were found to interact with GR. The SETD1A complex regulates a subset of GR target genes by affecting their transcription activation, while the MLL-BRG1-Switch-SNF complex recruits BRG1 to GR target sites for transcription repression. The presence of BRG1 in the complex facilitates the recruitment and activity of histone deacetylases, leading to transcriptional repression. Knockdown of BRG1 impairs the repression of GR target genes. The study highlights that different subsets of GR target genes rely on distinct co-regulator complexes for regulation, underscoring the complexity of GR regulation and the importance of careful analysis and investigation of target gene subsets.

Keywords

co-regulators

nuclear receptors

transcription factors

modifying enzymes

transcriptional complexes

metabolism

inflammation

prostate cancer cell proliferation

NCoR2

gene expression

diabetes

metabolic illnesses


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