The Gut Microbiome and Metabolism-The Gut Microbiome and Metabolism

Video Transcription

Video Summary

The first video is a presentation by Dr. Ronald Kahn on the involvement of the gut microbiome in gene-environment interactions that contribute to metabolic syndrome and insulin resistance. Dr. Kahn explores the impact of changes in the gut microbiome on metabolic health and insulin signaling, emphasizing the need for further research.<br /><br />The second video discusses the role of the gut microbiota in regulating circadian rhythms and lipid metabolism. The speaker explains how the microbiota activates a histone deacetylase called HDAC3, which affects gene expression related to energy uptake and metabolism. The deletion of HDAC3 in the intestinal epithelium leads to resistance to diet-induced weight gain and obesity, potentially through altered lipid absorption and gene expression.<br /><br />Both videos were presented by knowledgeable speakers (Dr. Ronald Kahn in the first video) and are based on their research. The first video was funded by the NIH, while no specific credits were mentioned in the second video.

Keywords

gut microbiome

gene-environment interactions

metabolic syndrome

insulin resistance

metabolic health

insulin signaling

circadian rhythms

lipid metabolism

histone deacetylase HDAC3

energy uptake and metabolism

intestinal epithelium


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