Steroidogenesis and Androgen Actions-Steroidogenesis and Androgen Actions

Video Transcription

Video Summary

Summary 1:<br />The video transcript discusses the role of the androgen receptor (AR) in breast cancer and the potential for targeting AR signaling as a therapeutic strategy. The speaker shares their own research findings, emphasizing the high expression of AR in breast cancer and the ability of AR agonists and selective estrogen receptor modulators to inhibit tumor growth in preclinical models. They also highlight the genomic interaction between AR and estrogen receptor (ER) signaling in breast cancer. The transcript does not mention any credits granted for the video content.<br /><br />Summary 2:<br />The video content discusses the conventional and alternative pathways to androgen production and their role in breast cancer. It explains the production of testosterone from cholesterol and its conversion to dihydrotestosterone through the 5-alpha reductase enzyme. The alternative pathway, known as the backdoor pathway, is also described, involving the conversion of 17-hydroxyprogesterone to androstenedione and its conversion to dihydrotestosterone in target tissues. The video highlights the role of cytochrome B5 and its interaction with the enzyme P45017A1 in stimulating the 17-20 lyase activity. The relevance of the alternative pathway in various conditions is discussed, including premature adrenarche, primary adrenal insufficiency, and aging. The video concludes with a tribute to Dr. Gene Wilson, a renowned endocrinologist and former president of the Endocrine Society.

Keywords

androgen receptor

breast cancer

targeting AR signaling

therapeutic strategy

AR expression

AR agonists

selective estrogen receptor modulators

tumor growth inhibition

genomic interaction

estrogen receptor signaling

alternative pathways

testosterone

cholesterol


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