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Spermatogenesis: Targets for Fertility and Contrac ...
Spermatogenesis: Targets for Fertility and Contrac ...
Spermatogenesis: Targets for Fertility and Contraception
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Video Transcription
Video Summary
Dr. Chris Gehr from East Carolina University presents his lab's research on identifying potential targets for male contraception by studying spermatogonial differentiation and meiotic initiation. The aim is to develop reversible methods with minimal side effects. Genetic models and flow cytometry are used to synchronize and isolate different cell types in the testis, followed by transcriptomics and proteomics analysis. Dr. Gehr emphasizes the challenges of translating findings from mouse models to humans but mentions collaboration with drug development experts for potential drug discovery and development.<br /><br />Dr. Stephanie Page discusses the development of male hormonal contraceptives using progestins and androgens in gels, injections, and oral pills. The effectiveness, reversibility, acceptability, and side effects of these contraceptives are covered. Dr. Page mentions ongoing trials, such as the Nesterone Testosterone Gel Study, to determine the efficacy and safety of the gel. She stresses the need to address regulators' and investors' concerns to expedite the development timeline. Additionally, she highlights the potential benefits of male contraceptives beyond preventing pregnancy, such as effects on bone density and body composition. Dr. Stephanie Page acknowledges her colleagues and funding sources in her research.
Keywords
male contraception
spermatogonial differentiation
meiotic initiation
reversible methods
minimal side effects
genetic models
transcriptomics
proteomics analysis
male hormonal contraceptives
gels
injections
oral pills
efficacy
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