Spermatogenesis: Targets for Fertility and Contraception-Spermatogenesis: Targets for Fertility and Contraception

Video Transcription

Video Summary

Dr. Chris Gehr from East Carolina University presents his lab's research on identifying potential targets for male contraception by studying spermatogonial differentiation and meiotic initiation. The aim is to develop reversible methods with minimal side effects. Genetic models and flow cytometry are used to synchronize and isolate different cell types in the testis, followed by transcriptomics and proteomics analysis. Dr. Gehr emphasizes the challenges of translating findings from mouse models to humans but mentions collaboration with drug development experts for potential drug discovery and development.<br /><br />Dr. Stephanie Page discusses the development of male hormonal contraceptives using progestins and androgens in gels, injections, and oral pills. The effectiveness, reversibility, acceptability, and side effects of these contraceptives are covered. Dr. Page mentions ongoing trials, such as the Nesterone Testosterone Gel Study, to determine the efficacy and safety of the gel. She stresses the need to address regulators' and investors' concerns to expedite the development timeline. Additionally, she highlights the potential benefits of male contraceptives beyond preventing pregnancy, such as effects on bone density and body composition. Dr. Stephanie Page acknowledges her colleagues and funding sources in her research.

Keywords

male contraception

spermatogonial differentiation

meiotic initiation

reversible methods

minimal side effects

genetic models

transcriptomics

proteomics analysis

male hormonal contraceptives

gels

injections

oral pills

efficacy


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