Rare Bone Diseases-Paget Disease

Video Transcription

Video Summary

The video is a part of the Endocrine Society's fellow training series on Paget's disease. It provides information about the risk factors, diagnosis, and management of the disease. The prevalence of Paget's disease is about 3% in certain regions, and it typically occurs after age 55 with a higher incidence in men. The disease involves accelerated bone turnover and remodeling, leading to abnormal bone deposition and increased bone volume. Symptoms can include bone pain and deformities, and common sites of the disease are the skull, spine, pelvis, femur, and tibia. Complications can include high output heart failure and osteosarcoma. Pharmacotherapy with bisphosphonates is recommended for symptomatic patients with specific lesions. Zoledronate is highlighted as an effective treatment option, providing normalization of alkaline phosphatase levels and improvements in quality of life. Calcitonin is mentioned as another treatment option, particularly for patients with renal impairment. This medication can help reduce pain, stabilize hearing, and decrease bone vascularity. Surgery may be required for specific complications, including joint arthroplasty, fixation for fractures, osteotomy for deformities, spinal decompression, and tumor resections. Regular monitoring of serum alkaline phosphatase levels and bone turnover markers is recommended. The video concludes by emphasizing the importance of early diagnosis and appropriate management to relieve symptoms and prevent complications.

Keywords

Paget's disease

diagnosis

management

complications

bisphosphonates


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