Puberty and Growth-Puberty and Growth

Video Transcription

Video Summary

Summary of the first video: The video discusses a study on the use of Chronosophant, a drug that inhibits the release of ACTH, in adolescents with classic 21-hydroxylase deficiency. Eight participants received Chronosophant for 14 days, and hormone samples were collected to assess its effects. Preliminary data showed reductions in ACTH and androgen levels in adults with this deficiency, and the study aimed to evaluate the same effects in adolescents. The participants were primarily on hydrocortisone-only regimens. Further analysis will provide insights into Chronosophant as a treatment for 21-hydroxylase deficiency.<br /><br />Summary of the second video: The video discusses Madelung deformity in patients with Turner syndrome. Madelung deformity is often underdiagnosed in these patients, despite radiographic evidence. The study included 187 patients with Turner syndrome and found a high rate of underdiagnosis of Madelung deformity. The average age of diagnosis was around 15 years old for ulnar tilt and 13.6 years old for lunate subsidence. The speaker emphasized the need for better screening tools and increased awareness among clinicians to improve early detection and intervention. The study suggested analyzing yearly bone age radiographs and obtaining lateral views for verification. Early diagnosis of Madelung deformity could guide timely surgical intervention and improve outcomes for patients with Turner syndrome.

Keywords

Chronosophant

ACTH

21-hydroxylase deficiency

adolescents

hormone levels

hydrocortisone

Madelung deformity

Turner syndrome

underdiagnosis

screening tools

early detection

surgical intervention


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