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PCOS and Metabolic Consequences – The Skinny on Ad ...
PCOS and Metabolic Consequences – The Skinny on Ad ...
PCOS and Metabolic Consequences – The Skinny on Adipocytes
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Video Summary
In this video, Dr. Ricardo Aziz discusses research on adipocyte insulin resistance in polycystic ovarian syndrome (PCOS) and its relationship with glucose disposal and microRNAs. He explores the dysfunction of adipose tissue in PCOS patients and the role of microRNA 93 in adipose tissue dysfunction. Dr. Aziz concludes that epigenetics plays a role in adipose tissue dysfunction in PCOS and further research is needed to understand the mechanisms involved. <br /><br />Dr. Stephen Franks discusses the link between obesity and PCOS, highlighting the higher prevalence of obesity among PCOS patients compared to the general population. He also explores the role of energy balance in PCOS and factors that may contribute to reduced energy expenditure in PCOS. Dr. Franks suggests that insulin resistance, aberrant insulin signaling, and altered sympathetic activity may play a role in reduced energy expenditure. He concludes by discussing potential strategies for modifying energy balance in PCOS to treat obesity.<br /><br />The video also includes a presentation on the effects of prenatal testosterone excess on adipose tissue in a sheep model of PCOS. The presenter discusses the different types of adipocyte depots and their functions, as well as the impact of prenatal testosterone on adipose tissue differentiation and insulin sensitivity. They also talk about the role of non-coding RNAs in adipose tissue gene regulation and how they contribute to the PCOS phenotype. The findings show that prenatal testosterone excess leads to disruptions in gene expression, specifically in inflammatory and oxidative stress pathways, adipocyte differentiation, and thermogenic markers. This contributes to lipotoxicity and insulin resistance in PCOS. <br /><br />No specific credits are mentioned in the given summary.
Keywords
adipocyte insulin resistance
PCOS
glucose disposal
microRNAs
dysfunction of adipose tissue
microRNA 93
epigenetics
obesity
energy balance
insulin resistance
prenatal testosterone excess
lipotoxicity
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