On-Demand | Update in Primary Aldosteronism-Video: Update in Primary Aldosteronism

Video Transcription

Video Summary

Dr. Gedmisa Karyas from the University of Minnesota discussed primary aldosteronism during an Endocrine Society presentation. The session covered current screening practices, diagnostic approaches using case-based scenarios, and evidence-based treatment strategies. Primary aldosteronism, a treatable cause of hypertension, results from autonomous aldosterone production, often due to genetic mutations. Despite its significance, less than 2% of high-risk patients are screened. Screening and diagnostic accuracy can be improved through clinical tools, although screening rates remain low. Dr. Karyas emphasized the need for repeat testing in cases of high clinical suspicion and noted that confirmatory testing might not always be required. For treatment, unilateral adrenalectomy is recommended for lateralizing diseases, while medical treatment involves mineralocorticoid receptor antagonists. Accurate subtyping using adrenal venous sampling is crucial for surgery decisions. Long-term monitoring and careful management are essential, especially due to the risk of persistent disease and recurrence. The presentation highlighted the importance of early diagnosis to prevent complications and improve clinical outcomes.

Keywords

primary aldosteronism

hypertension

screening practices

diagnostic approaches

treatment strategies

adrenalectomy

mineralocorticoid receptor antagonists

adrenal venous sampling

early diagnosis


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