On-Demand | Prolactinemia and Prolactinoma Work-up and Management-Video: Prolactinemia and Prolactinoma Work-up and Management

Video Transcription

Video Summary

The webinar provides a comprehensive overview of prolactin-related conditions, specifically focusing on hyperprolactinemia and prolactinomas. The speaker covers the physiology of prolactin, which is under dual control involving dopamine and TRH, among other factors. Prolactin's main role is in lactation but also affects bone metabolism, hair cycle, and more. Hyperprolactinemia can arise from physiological states like pregnancy or pathological conditions such as prolactinomas, which are pituitary tumors.<br /><br />The session delineates how to classify prolactinomas by size and potential malignancy, outlining criteria for micro and macro prolactinomas. It discusses dopamine agonists like cabergoline and bromocriptine as primary treatments, highlighting their efficacy and potential side effects. Surgery becomes a recommended option for specific cases, particularly with available advanced surgical expertise, prioritizing smaller, well-confined tumors.<br /><br />Additionally, the presentation touches on prolactinoma management during pregnancy, which involves careful monitoring and possibly maintaining some treatment if the tumor is large. Dopamine agonist side effects, mental and bone health considerations, and rare malignant prolactinomas are also examined. The talk closes with a call for differentiating between physiological and pathological hyperprolactinemia causes, understanding assay limitations, and the importance of integrating multidisciplinary care where needed.

Keywords

prolactin

hyperprolactinemia

prolactinomas

dopamine

TRH

lactation

bone metabolism

dopamine agonists

cabergoline

bromocriptine

pituitary tumors


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