Molecular Mechanisms of Male Reproductive Tract Development and Effects of Testosterone Therapies on Health and Reproduction-Molecular Mechanisms of Male Reproductive Tract Development and Effects of Testosterone Therapies on Health and Reproduction

Molecular Mechanisms of Male Reproductive Tract Development and Effects of Testosterone Therapies on Health and Reproduction

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Video Summary

In the first video, the study focused on the impact of testosterone on IVF outcomes in a gender-affirming mouse model. The researchers administered testosterone to female mice and found that active testosterone treatment resulted in impaired IVF outcomes, including a decrease in the number of eggs retrieved and lower fertilization rates. However, when testosterone treatment was stopped, the outcomes improved and became comparable to the control group. This study highlights the potential negative effect of testosterone treatment on fertility during IVF, but also demonstrates that these effects are reversible upon cessation of treatment. The study was conducted by Amanda Schwartz and her team at the University of Michigan.<br /><br />In the second video, the researchers investigated the effects of testosterone therapy on body composition, metabolic profile, bone turnover, and bone mineral density in men with different baseline testosterone levels. They included 105 men who underwent testosterone therapy for 18 months and were divided into two groups based on their baseline testosterone levels. The study found that testosterone therapy improved body composition in both groups, with greater increases in fat-free mass observed in men with lower baseline testosterone levels. The group with higher baseline testosterone levels experienced improvements in metabolic parameters such as A1C and fasting blood glucose. However, there were no significant differences in bone mineral density or bone turnover markers between the groups. The study suggests that the severity of hypogonadism at baseline may influence the response to testosterone therapy, with different effects observed on body composition and metabolic profile. It is important to note that current guidelines recommend testosterone therapy for body composition improvement in men with HIV but do not support its use for metabolic benefits in hypogonadal men with type 2 diabetes. These findings provide additional evidence and can guide clinicians in tailoring testosterone therapy for men with different baseline testosterone levels.

Keywords

testosterone

IVF outcomes

gender-affirming mouse model

female mice

eggs retrieved

fertilization rates

negative effect

reversible

testosterone treatment

fertility

Amanda Schwartz

University of Michigan

body composition

metabolic profile


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