Member Special - Improving Patient Care-Treatment Options in Osteoporosis Across the Spectrum of Fracture Risk

Video Transcription

Video Summary

Video Summary:<br /><br />The video transcript summarizes a presentation given by Dr. Ian Reid on treatment options for osteoporosis. Dr. Reid emphasizes the need to treat individuals at moderate risk of fracture, as most fractures occur in this population. He discusses the NORA study, highlighting the significant risk of fractures in women with moderate fracture risk. Various screening studies aimed at determining treatment recommendations based on fracture risk are also mentioned, although many did not result in significant decreases in fracture numbers.<br /><br />Dr. Reid explores different treatment options, including calcium supplementation and vitamin D. He explains that while calcium supplementation can have a small, transient positive effect on bone density, it does not lead to long-term fracture prevention. The efficacy of vitamin D supplementation is also discussed, with evidence suggesting benefits for individuals with vitamin D deficiency but not for those with adequate levels.<br /><br />The use of drug interventions, such as bisphosphonates, denosumab, and teriparatide, in preventing fractures is then discussed. While these drugs have been shown to reduce fracture numbers, Dr. Reid notes potential side effects, such as atypical femoral fractures with bisphosphonates and rebound-associated vertebral fractures with denosumab discontinuation. Overall, treating osteopenic individuals with various drug interventions can help reduce fracture risk, but considerations of safety, cost, and patient adherence are important in determining the optimal treatment approach.<br /><br />In addition, the video discusses the use of anabolic agents (teriparatide and romosozumab) and antiresorptive agents (alendronate and denosumab) for treating osteoporosis. It emphasizes the importance of transitioning between these agents to maintain and increase bone density. Clinical trials demonstrating romosozumab's efficacy in increasing bone density and reducing fracture risk are mentioned, along with potential side effects such as cardiovascular events and bone fractures.<br /><br />Overall, the video provides a comprehensive overview of different treatment options for osteoporosis and highlights the importance of individualized treatment approaches.

Keywords

osteoporosis treatment

fracture risk

NORA study

screening studies

calcium supplementation

vitamin D supplementation

drug interventions

bisphosphonates

denosumab

teriparatide

anabolic agents

antiresorptive agents


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