Member Special - Improving Patient Care-Treating Type 2 Diabetes: New Approaches for an Old Foe

Video Transcription

Video Summary

In this video summary, Dr. Adrian Vela, a professor of medicine, discusses the defects in type 2 diabetes and how they are characterized by high fasting glucose and inappropriate fasting insulin levels. He explains that insulin secretion is decreased and delayed in people with type 2 diabetes, leading to hyperglycemia. Dr. Vela highlights the importance of glucagon in type 2 diabetes and its role in glucose production. He also discusses the impact of hepatic metabolism and the liver on glucose homeostasis. Dr. Vela explains how glucokinase activation can improve hepatic insulin action and decrease fasting glucose levels. He explores the interactions between insulin signaling, defects, and the liver in type 2 diabetes pathogenesis. Dr. Vela concludes by evaluating the potential of glucokinase activation as a therapy for type 2 diabetes and the role of hepatic islet crosstalk in regulating glucose metabolism. This summary is based on the transcript of a video presentation and no credits are granted.

Keywords

type 2 diabetes

defects

high fasting glucose

inappropriate fasting insulin levels

insulin secretion

hyperglycemia

glucagon

glucose production

hepatic metabolism

glucose homeostasis


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