Member Special - Advances in Hormone Science Research-Pharmacogenomics of Hormone Receptor Signaling

Video Transcription

Video Summary

The video summary discusses Dr. Madan Babu's research on G-protein coupled receptors (GPCRs) and their genetic variation's impact on drug response and development. GPCRs are important for regulating human physiology and are targeted by FDA-approved drugs. Dr. Babu's research group uses data science approaches to investigate GPCR signaling at different levels, analyzing sequences, structures, expression, and networks of interactions. They have discovered extensive genetic variation in GPCRs targeted by drugs, particularly at ligand binding sites and functional sites. Understanding this variation is crucial for personalized medicine and reducing adverse drug reactions. The group also studies tissue-specific differences in GPCR signaling, identifying unique combinations of GPCR isoforms expressed in different tissues and exploring their implications for drug targets. Dr. Babu emphasizes the need to consider isoform diversity and tissue context in understanding GPCR signaling. He also highlights resources and job openings available through the GPCR database and the Center for Data-Driven Discovery at St. Jude Children's Research Hospital.<br /><br />Additionally, the session discussed genetic variants' impact on diseases like type 2 diabetes. The speakers discussed the use of classical dose-response curves and functional studies to understand the effects of genetic variants on GLP-1 signaling and receptor function. They found associations between rare coding variants in the GLP-1R gene and diabetes risk, as well as intronic variants in the MTNR1B gene. These variants were characterized for their impact on G protein signaling and beta-arrestin pathway activation. The session highlighted the importance of functional studies in uncovering the underlying mechanisms of genetic variant-disease associations.

Keywords

G-protein coupled receptors

genetic variation

drug response

drug development

GPCR signaling

ligand binding sites

functional sites

personalized medicine

tissue-specific differences

GPCR isoforms

type 2 diabetes

functional studies


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