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On-Demand | Exogenous Hormone Use and Mid-life Hea ...
Recording | Exogenous Hormone Use and Mid-life H ...
Recording | Exogenous Hormone Use and Mid-life Health in Women: An Epidemiologist's Perspective
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Video Summary
Kara Michaels, an epidemiologist, delivered a talk on exogenous hormone use and its impact on women's midlife health, focusing on oral contraceptives and menopausal hormone therapy. She presented two case studies: the association between oral contraceptives and postmenopausal cancer risk, and the relationship between menopausal hormone therapy and cardiovascular outcomes.<br /><br />Michaels explained how oral contraceptives, classified by pharmaceutical generations, have implications for cancer risk, particularly ovarian and endometrial cancers. She highlighted the stability in oral contraceptive usage and how newer formulations might affect pre-menopausal cancer risks, unlike older studies focusing on postmenopausal risks.<br /><br />In discussing menopausal hormone therapy, Michaels highlighted the historical controversy involving the Nurses' Health Study and the Women's Health Initiative (WHI). She explained differing findings regarding coronary heart disease risk, attributed to population age at initiation and study design. WHI trials, focusing on older women, showed increased risks of coronary heart disease, contrary to cohort studies like NHS, which indicated benefits in younger women.<br /><br />Michaels emphasized the importance of considering study design, exposure definitions, and population characteristics, encouraging researchers to ask old questions with new approaches, stressing transparency and context in hormonal research discussions.
Keywords
epidemiologist
exogenous hormones
women's midlife health
oral contraceptives
menopausal hormone therapy
cancer risk
cardiovascular outcomes
Nurses' Health Study
Women's Health Initiative
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