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Late Breaking: Tools and Targets in Basic Endocrin ...
Late Breaking: Tools and Targets in Basic Endocrin ...
Late Breaking: Tools and Targets in Basic Endocrinology Research
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Video Transcription
Video Summary
In the first video, the speaker discusses the role of TGF-beta signaling in endometrial cell homeostasis and regeneration. They found that TGF-beta signaling is important for endometrial regeneration and that inhibition of this signaling pathway alters organoid morphology and gene expression.<br /><br />The second video focuses on the role of melatonin receptor 1 in glucose and lipid metabolism. The speaker found that knockout mice lacking the MT1 receptor showed disrupted glucose metabolism and increased lipid levels in the liver.<br /><br />The third video discusses the use of engineered CAR-T-reg cells for treating type 1 diabetes. The CAR-T-reg cells were able to recognize a specific antigen and improve glucose metabolism in the pancreatic islets.<br /><br />The last video explores the role of tumor intrinsic glucocorticoid receptor activity in ovarian cancer. The speaker found that activation of this receptor increased the secretion of cytokines that promote the infiltration of immunosuppressive cells into the tumor microenvironment, contributing to an immunosuppressive phenotype in ovarian cancer.<br /><br />No specific credits were mentioned in the summary.
Keywords
TGF-beta signaling
endometrial cell homeostasis
endometrial regeneration
organoid morphology
gene expression
melatonin receptor 1
glucose metabolism
lipid levels
engineered CAR-T-reg cells
type 1 diabetes
pancreatic islets
tumor intrinsic glucocorticoid receptor activity
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