false
OasisLMS
zh-CN,zh-TW,en,fr,de,hi,ja,ko,pt,es
Catalog
Integrating Clinical Genetics in Clinical Practice
Genetic Sequencing
Genetic Sequencing
Back to course
[Please upgrade your browser to play this video content]
Video Transcription
Video Summary
The video discusses the correlation between genotype and phenotype. It explains allelic heterogeneity, where different variants in a gene can result in the same phenotype, and locus heterogeneity, where variants in different genes can cause the same phenotype. It also introduces clinical or phenotypic heterogeneity, where different mutations in a gene can lead to different phenotypes. The video then delves into the various methods of DNA sequencing, including Sanger sequencing, fluorescent-labeled dideoxynucleotide sequencing, and next-generation sequencing. It highlights the advancements and ease of next-generation sequencing, including whole-exome sequencing and whole-genome sequencing, which have revolutionized the field of genetics and made it easier to identify novel genetic variants. The American College of Medical Genetics also provides a list of genes that can be identified as secondary findings during sequencing due to their relevance in preventative measures and treatments. The video concludes by discussing the benefits of whole-exome and whole-genome sequencing for research purposes. No credits are mentioned in the video.
Keywords
genotype
phenotype
allelic heterogeneity
locus heterogeneity
DNA sequencing
×