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OasisLMS
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Catalog
Integrating Clinical Genetics in Clinical Practice
Gene Mutations
Gene Mutations
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Video Transcription
Video Summary
The video discusses the reasons for the occurrence of mutations. Errors can arise during processes such as DNA replication, transcription, translation, and recombination. Mutagens like chemicals, UV rays, and ionizing radiation can also lead to mutations. Aging itself can cause mutations as well. Germline mutations occur in germ cells and can be inherited, while somatic mutations occur in somatic cells and cannot be inherited. The video also explains different types of mutations, such as deletions, substitutions, insertions, inversions, and translocations. It describes single nucleotide variants, including silent mutations, nonsense mutations, and missense mutations. The concept of zygosity and different genotypes, such as loss of function, gain of function, haploinsufficiency, and dominant negative mutations, are also discussed. The video ends by mentioning loss of heterozygosity in cancer.
Keywords
mutations
DNA replication
mutagens
germline mutations
somatic mutations
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