Insights on New Targets in Estrogen-dependent Cancer Regulation-Insights on New Targets in Estrogen-dependent Cancer Regulation

Insights on New Targets in Estrogen-dependent Cancer Regulation

Video Transcription

Video Summary

Summary:<br /><br />In the first video, the speaker discusses the role of the gene ULAB in estrogen-dependent genome regulation in breast cancer. They find that ULAB is upregulated by estrogen and its expression correlates with poor outcomes in certain types of breast cancer. Knockdown of ULAB inhibits the growth of ER-positive breast cancer cells, while overexpression of ULAB promotes growth. Xenograft experiments confirm these findings.<br /><br />In the second video, the speaker discusses a study on the effects of the glutamate blocker RLZ on ER-positive breast cancer. They find that RLZ inhibits growth, induces apoptosis and affects the cell cycle in various breast cancer cell lines, including tamoxifen-resistant ones. RLZ also impacts the focal adhesion kinase 1 pathway. Combination treatment of RLZ and fulvestrant, an endocrine therapy, results in even greater inhibition of cell growth, both in vitro and in vivo.<br /><br />No credits were mentioned in the provided summaries.

Keywords

gene ULAB

estrogen-dependent genome regulation

breast cancer

poor outcomes

knockdown of ULAB

growth inhibition

ER-positive breast cancer cells

glutamate blocker RLZ

cell cycle

tamoxifen-resistant

focal adhesion kinase 1 pathway

fulvestrant


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