Hot Topics in Endocrine Hypertension-Hot Topics in Endocrine Hypertension

Video Transcription

Video Summary

Primary aldosterism is a syndrome characterized by excessive production of aldosterone, leading to activation of the mineralocorticoid receptor in the kidney. This can result in volume expansion, high blood pressure, and potential cardiovascular and kidney diseases. However, primary aldosterism is often unrecognized due to limited screening and variability in diagnostic approaches. Some consider it a discrete disease, while others view it as a continuous syndrome. The lack of a diagnostic gold standard further complicates estimation of prevalence. Further research is needed to accurately define and diagnose primary aldosterism.<br /><br />In a session on endocrine hypertension, experts discussed various aspects of primary aldosteronism. Dr. Maria-Christina Cinaro emphasized the importance of screening in patients with resistant hypertension or adrenal incidentalomas. Dr. William Young focused on the genetic basis and management, highlighting the use of genotype-guided therapy. Dr. Anand Vaidya discussed diagnostic challenges and variability in prevalence estimates. He also explored targeted metabolomics as a tool for discriminating different forms of endocrine hypertension. Dr. Felix Beuschling presented studies on metabolic changes and the potential of metabolomics as a screening tool.<br /><br />Overall, the session provided valuable insights into the diagnosis, management, and research approaches in endocrine hypertension. However, more research is needed to improve screening and diagnostic accuracy for primary aldosterism.

Keywords

primary aldosterism

aldosterone

mineralocorticoid receptor

kidney

high blood pressure

cardiovascular diseases

diagnostic approaches

endocrine hypertension

resistant hypertension

genetic basis

genotype-guided therapy

metabolic changes

screening tool


EndoCareers \| Contact Us \| Privacy Policy \| Terms of Use	CONNECT WITH US
© 2021 Copyright Endocrine Society. All rights reserved.	2055 L Street NW, Suite 600 \| Washington, DC 20036 202.971.3636 \| 888.363.6274