Fill ‘er Up! Satiety and Satiety Mechanisms-Fill ‘er Up! Satiety and Satiety Mechanisms

Fill ‘er Up! Satiety and Satiety Mechanisms

Video Transcription

Video Summary

In a recent study, the structure of the melanocortin-4 receptor (MC4R) was determined, showing the presence of calcium in its binding site. The role of calcium in the receptor's function was investigated, revealing that its presence increased the receptor's sensitivity and affinity for agonist ligands, while its absence had the opposite effect. These effects were observed with both endogenous and synthetic ligands. The study also discovered a toggle switch in the receptor's transmembrane domain 6, which undergoes a significant movement during receptor activation, leading to downstream signaling. The findings provide insights into the molecular mechanisms involved in satiety signaling regulated by MC4R, highlighting the importance of calcium in this process.

Keywords

melanocortin-4 receptor

MC4R

structure

calcium

binding site

receptor's function

sensitivity

affinity

agonist ligands

toggle switch

receptor activation

satiety signaling


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