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EndoBytes: Patient-Centered Approach to Hypercorti ...
Presentations and Consequences of Hypercortisolism
Presentations and Consequences of Hypercortisolism
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Video Summary
This module explores hypercortisolism's clinical presentation and consequences, highlighting its heterogeneous features ranging from classic signs like proximal muscle weakness, facial redness, and purple striae to nonspecific symptoms such as obesity, hypertension, and mood changes. It emphasizes sex differences: women more often have pituitary-related disease with menstrual and skin changes, while men tend toward severe, earlier onset with higher hormone levels and delayed diagnosis. Comorbidities include cardiometabolic issues, osteoporosis, neuropsychiatric disorders, and skin fragility, increasing cardiovascular risk and mortality even after remission. Diagnosis requires clinical intuition, recognizing symptom clusters, and careful use of biochemical tests to avoid misdiagnosis.
Keywords
hypercortisolism
clinical presentation
sex differences
comorbidities
diagnosis challenges
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