Digging Deeper: Use of Omics to Improve Therapy-Digging Deeper: Use of Omics to Improve Therapy

Video Transcription

Video Summary

Dr. Hisham Mohamed discusses the heterogeneity of hormone response in breast cancer. They developed a method called Titan to evaluate transcriptional networks in single cells and found two distinct networks associated with estrogen response. They identified KLFO as a regulator of heterogeneity in ER-positive breast cancer and found that loss of KLFO impacted ER binding and gene expression. Overall, their findings provide insights into the regulatory mechanisms underlying hormone response in breast cancer.<br /><br />Dr. Robert Clark presents a framework for understanding and predicting steroid hormone signaling in endocrine resistance in breast cancer. The framework is based on five fundamental features of cellular function: autophagy, cell survival death, metabolism, proliferation, and the unfolded protein response. He emphasizes the complexity of the system and the need for a systems biology approach. Dr. Clark discusses different subtypes of resistant breast cancer cells and the role of epigenetic rewiring. He finds that the framework features are consistently represented in clinical samples and experimental models, working together to help the cell adapt and survive under the stress of endocrine therapy. He suggests targeting multiple nodes or functions in the system to improve patient outcomes.

Keywords

heterogeneity

hormone response

breast cancer

Titan

transcriptional networks

estrogen response

KLFO

ER-positive breast cancer

ER binding

gene expression

endocrine resistance

systems biology approach

improve patient outcomes


EndoCareers \| Contact Us \| Privacy Policy \| Terms of Use	CONNECT WITH US
© 2021 Copyright Endocrine Society. All rights reserved.	2055 L Street NW, Suite 600 \| Washington, DC 20036 202.971.3636 \| 888.363.6274