Developmental Origins of the Endometrium: Omics From Within the Cradle-Developmental Origins of the Endometrium: Omics From Within the Cradle

Video Transcription

Video Summary

Two speakers, Dr. Thomas Spencer and Dr. Bruce Lessey, discuss the developmental origins of the endometrium and the role of epigenetics in endometriosis. Dr. Spencer's research focuses on endometrial epithelial organoids and their relevance to infertility and pregnancy loss. Dr. Lessey explains the connection between progesterone resistance, inflammation, and endometriosis. Epigenetic changes, such as DNA hypomethylation and hypermethylation, are observed in endometriosis and contribute to the disease phenotype. The upregulation of SIRT1 and its interaction with progesterone receptors and BCL6 are highlighted as key factors in endometriosis. Potential treatment targets and the role of epigenetics in progesterone resistance and steroid hormone dysfunction are also discussed. The video transcript features a discussion on the impact of inflammation on progesterone resistance, the mediation through microRNAs and the SIRT system, and the immune system reaction that may occur due to foreign endometrium in the pelvis. The battle between progesterone receptor and FOXO1 in endometriosis and the potential role of SIRT1 in deacetylating histones and other proteins are explored. The experts debate the genetic component of endometriosis and discuss the future potential of single-cell proteomics in understanding endometrial pathologies. No credits were mentioned in the video.

Keywords

endometrium

epigenetics

endometriosis

organoids

infertility

progesterone resistance

inflammation

epigenetic changes

SIRT1

progesterone receptors

BCL6

steroid hormone dysfunction

genetic component


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