Co-clinical Models to Interrogate Neo[Pro]plasia Models-Co-clinical Models to Interrogate Neo[Pro]plasia Models

Video Transcription

Video Summary

The video transcript summarizes a symposium on Co-Clinical Models to Interrogate Neoplasia and Proneoplasia, organized by the Endocrine Society and Dr. Hydera Del Rivero of the National Cancer Institute at the NIH. The symposium features three speakers discussing their research on neuroendocrine tumors.<br /><br />Dr. Sunita Agarwal explores the genetics, epigenetics, and biology of tumors associated with MEN1. Dr. Kate Lyons focuses on novel therapeutics for pancreatic neuroendocrine tumors, specifically MEN1 and epigenetics. Dr. Herbert Chen discusses the potential of the Notch signaling pathway as a therapeutic target in neuroendocrine tumors and presents data on its role in various cell lines and animal models. Dr. Don Kell's research focuses on discovering new therapies for neuroendocrine tumors by targeting the RabL6A-RB1 axis and presents data on targeting RabL6A and its downstream effectors for the development of novel combination therapies.<br /><br />The video also mentions the evaluation of the drug palbociclib in combination with inhibitors of other RABL6A-regulated enzymes for the treatment of neuroendocrine tumors. The researchers found that the combination of palbociclib with the MYC inhibitor CPI-203 and a MEK inhibitor showed good synergy, leading to cell cycle arrest, increased cell death, and reduced MYC expression. In vivo experiments showed a delay in tumor progression and extended survival. Ongoing and future studies include analyzing patient-derived spheroids and PDX models and studying the combination in immune-competent mice and its effects on metastases. Compelling data in sarcoma and immune-competent mouse models of PNETS was also mentioned.<br /><br />No credits were given in the transcript for the symposium or the video content. The summary provides an overview of the topics discussed by each speaker and highlights the key findings and ongoing research.

Keywords

Co-Clinical Models

Neoplasia

Proneoplasia

Endocrine Society

Dr. Hydera Del Rivero

National Cancer Institute

NIH

Neuroendocrine Tumors

MEN1

Genetics

Epigenetics

Notch Signaling Pathway

RabL6A-RB1 Axis


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