Clinical Practice Guidelines - Resource Library-Vitamin D for the Prevention of Disease

Video Transcription

Video Summary

The video transcript explores the discussion by a panel of experts on the Prevention of Disease in Endocrine Society Clinical Practice Guidelines, particularly focusing on vitamin D supplementation recommendations for different population groups. The panel evaluated evidence from randomized clinical trials using the GRADE process to make conditional recommendations based on benefits and harms. They emphasized the importance of evidence-based recommendations and highlighted the challenges of interpreting observational studies versus clinical trials. Recommendations varied by age group, with considerations for factors like health equity and cost-effectiveness. The panel recommended targeted vitamin D supplementation for specific populations based on available evidence and acknowledged the limitations of current research. They found evidence supporting vitamin D supplementation during pregnancy, for preventing progression to diabetes, and reducing mortality in older adults. The panel did not recommend routine screening for vitamin D deficiency in healthy adults due to insufficient evidence. Dosing recommendations varied based on outcomes studied, with a call for future research focusing on diverse populations and outcomes. The panel cautioned against using race as a proxy for biological factors like skin complexion.

Keywords

Prevention of Disease

Endocrine Society Clinical Practice Guidelines

Vitamin D supplementation

Population groups

Randomized clinical trials

GRADE process

Evidence-based recommendations

Observational studies

Age groups

Health equity

Cost-effectiveness

Pregnancy


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