Clinical Pearls from JCEM Case Reports: Pituitary Edition-Case Discussion: Pituitary Apoplexy Secondary to Gonadotropin-Releasing Hormone Agonist for Breast Cancer

Case Discussion: Pituitary Apoplexy Secondary to Gonadotropin-Releasing Hormone Agonist for Breast Cancer

Video Transcription

Video Summary

In this webinar, Dr. Farhad Hassan presented a case report titled "Pituitary Apoplexy, Secondary to Gonadotropin-Releasing Hormone Agonists for Breast Cancer." The patient was a 52-year-old female with a history of pituitary macroadenoma who presented with worsening headaches and fatigue. She had a previous transphenoidal surgery for the adenoma and was currently on levothyroxine for borderline low serum free thyroxin. After being diagnosed with breast cancer, she received leuprolyte as part of her treatment. Four days later, she presented with acute onset severe headache, vision problems, and other symptoms consistent with pituitary apoplexy. She was diagnosed with anterior hypopituitarism and was discharged on hydrocortisone and levothyroxine. Her follow-up MRI showed shrinkage of the adenoma. The webinar discussed the risk of developing apoplexy after pituitary surgery, the importance of monitoring in patients receiving GnRH agonists, and the need for thorough assessment and management by an endocrinologist in cases of pituitary apoplexy.

Keywords

webinar

Dr. Farhad Hassan

case report

Pituitary Apoplexy

Gonadotropin-Releasing Hormone Agonists

Breast Cancer


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