Cardiometabolic Impact of Gender Affirming Hormone Therapy (GAHT) in Transgender Adults-Cardiometabolic Impact of Gender Affirming Hormone Therapy (GAHT) in Transgender Adults

Video Transcription

Video Summary

In these video summaries, the speaker focuses on the cardiometabolic impact of gender reassignment surgery and hormone therapy in transgender adults. They acknowledge the lack of strong evidence-based research in this area and the off-label use of hormone therapy in transgender medicine. The video highlights the different effects of sex hormones on metabolism and fat distribution between males and females, discussing changes in fat distribution, weight gain, and metabolic function that transgender individuals may experience due to hormone therapy. Thromboembolic risk and increased cardiovascular risk in transgender individuals are also addressed, though not directly linked to hormone therapy. Individualized care and risk assessment are emphasized, considering factors like smoking, obesity, and pre-existing medical conditions. Breast development and the potential impact of hormone therapy on size change, as well as its effects on weight and adipose tissue changes, are mentioned. The importance of further research to fully understand the long-term cardiometabolic impact is stressed.<br /><br />Regarding specific health outcomes, the video explains that hormone therapy affects insulin sensitivity, weight gain, cardiovascular risk, lipid levels, blood pressure, and potentially bone health in transgender individuals. Estrogen-based hormone therapy is associated with reduced insulin sensitivity in transgender women, while weight gain is observed in both transgender women and men. Cardiovascular risk is higher in transgender individuals, particularly transgender women. Hormone therapy itself is not identified as the direct cause. Lipid levels are influenced by hormone therapy, with trans men displaying an atherogenic lipid profile and trans women generally having a favorable lipid profile. Blood pressure changes are noted but not considered significant, while bone health is not discussed in these summaries. More research is deemed necessary to understand the effects of hormone therapy on various health outcomes, emphasizing the importance of individualized care and shared decision-making in transgender healthcare.

Keywords

cardiometabolic impact

gender reassignment surgery

hormone therapy

transgender adults

evidence-based research

fat distribution

weight gain

metabolic function

thromboembolic risk

cardiovascular risk

individualized care

health outcomes


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