Advances in the Treatment of Congenital Adrenal Hyperplasia-Advances in the Treatment of Congenital Adrenal Hyperplasia

Video Transcription

Video Summary

In the video, Alina Turcu, an associate professor at the University of Michigan, discusses congenital adrenal hyperplasia (CAH) and the challenges in managing the condition. CAH is a group of autosomal recessive disorders that affect cortisol synthesis and typically result in elevated levels of ACTH. Turcu explains that the excess ACTH leads to increased adrenal androgen production, causing symptoms such as virilization in newborn girls and androgen excess in women. Turcu presents a case of a 61-year-old woman with classic CAH who is experiencing diffuse alopecia and facial hirsutism. She discusses the goals of treatment, which are to replace deficient hormones and suppress excessive androgen production. Turcu reviews current and novel therapies for CAH, including modified-release hydrocortisone, continuous hydrocortisone infusion, CRH receptor antagonists, and androgen synthesis inhibitors. She also explains the use of 11-oxyandrogens as biomarkers for disease control in CAH patients. Turcu concludes by presenting two additional cases and eliciting audience participation in determining the best next steps for management. Unfortunately, the video transcript does not provide credits for the content.

Keywords

Alina Turcu

University of Michigan

congenital adrenal hyperplasia

CAH

cortisol synthesis

ACTH

adrenal androgen production

treatment goals

modified-release hydrocortisone


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