Advances in the Fundamental Understanding and Therapeutic Applications of Cilia-Advances in the Fundamental Understanding and Therapeutic Applications of Cilia

Video Transcription

Video Summary

Summary: The video is a symposium on Advances in the Fundamental Understanding and Therapeutic Applications of Cilia. The first speaker, Dr. Peter Jackson, discusses the role of ciliary FFAR4 in regulating adipogenesis and metabolism. He focuses on the importance of cilia in the pancreas for insulin secretion and in fat tissue for adipogenesis. Dr. Jackson also talks about the FR4 and PTGR4 receptors in ciliary signaling and their impact on insulin and glucagon secretion. Additionally, he explores the link between primary cilia and reproductive tract disorders. The video emphasizes the therapeutic potential of targeting primary cilia in various physiological processes.<br /><br />The second speaker discusses the role of primary neuronal cilia and the MC4R signaling in appetite regulation and obesity. They explain how alterations in primary cilia can lead to obesity and discuss the importance of the leptin-melanocortin system in regulating body weight. The presenter highlights that MC4R localizes and functions at the primary cilia and emphasizes the role of primary cilia in energy homeostasis. They suggest that alterations in MC4R expression and function at the primary cilia may be involved in the genetic predisposition to obesity in humans. The video underscores the significance of primary cilia in controlling food intake and body weight and explores the consequences of loss of primary cilia or inhibition of ciliary signaling on MC4R activity.<br /><br />Credits: The video features two speakers: Dr. Peter Jackson and an unnamed presenter discussing MC4R signaling. The credits for the video are not specified.

Keywords

ciliary FFAR4

adipogenesis

insulin secretion

glucagon secretion

primary cilia

reproductive tract disorders

MC4R signaling

obesity

leptin-melanocortin system

body weight

energy homeostasis

genetic predisposition

food intake


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