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Advances in Our Understanding of Intersex Conditio ...
Advances in Our Understanding of Intersex Conditio ...
Advances in Our Understanding of Intersex Conditions
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Video Transcription
Video Summary
The video is a presentation by Dr. Vincent Harley on the topic of disorders of sex development. Dr. Harley discusses various genes and concepts related to sex determination, focusing on the FGF signaling pathway and its role in human sex development. He presents research on mouse models and human mutations that affect sex development, including the FGFR2C mouse knockout and FGFR2 mutation found in an XY female. He also explores the role of FGF9 and activin B in Sertoli cell identity and testis development. Dr. Harley discusses the phenomenon of Freemartin and its relationship to the FGF signaling pathway. He concludes by discussing the importance of AMH and activin B in testis development and their potential as "Freemartin factors." The video also includes a presentation by Dr. Humphrey Yao on the role of AMH and activin B in sex determination and their potential as Freemartin factors. Dr. Yao discusses double knockout mouse models and transplantation experiments to support these roles. Overall, the video sheds light on new genes and concepts related to sex determination and offers insights into the mechanisms underlying disorders of sex development.
Keywords
disorders of sex development
FGF signaling pathway
human sex development
mouse models
FGFR2C mouse knockout
FGFR2 mutation
XY female
FGF9
activin B
Sertoli cell identity
testis development
Freemartin
AMH
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