Advances in Delaying the Onset of Type 1 Diabetes: What Do You Need to Know Now and in the Future?-Advances in Delaying the Onset of Type 1 Diabetes: What Do You Need Now and in the Future

Advances in Delaying the Onset of Type 1 Diabetes: What Do You Need Now and in the Future

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Video Summary

Thank you to the speakers for discussing the topic of advances in delaying the onset of type 1 diabetes. The talks focused on the use of immunotherapies, specifically teplizumab, to delay the onset of type 1 diabetes in patients with stage two diabetes. It was highlighted that teplizumab has been shown to delay the diagnosis of type 1 diabetes in both adults and pediatric patients who are at high risk for developing the disease. The presentation also outlined the potential mechanism of action of teplizumab, including the targeting of effector T cells and the induction of self-tolerance. The speakers discussed the side effects associated with teplizumab, including rash, lymphopenia, cytokine release syndrome, and the risk of infections and liver injury. The presentation emphasized the importance of monitoring patients who receive teplizumab for adverse effects and the occurrence of type 1 diabetes. The use of teplizumab as a preventive therapy in patients with stage two diabetes has been approved by the FDA. However, it should be noted that teplizumab is not a cure for type 1 diabetes and does not prevent the disease altogether. Further research is ongoing to explore other immunotherapies and combination treatments for delaying the onset of type 1 diabetes. In conclusion, teplizumab has shown promise in delaying the diagnosis of type 1 diabetes in high-risk patients with stage two diabetes. However, more research is needed to further understand its long-term effects and potential for combination therapies.

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On-demand

Keywords

advances

delaying

onset

type 1 diabetes

immunotherapies

teplizumab

stage two diabetes

adults

pediatric patients

self-tolerance

side effects


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